Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Benoxinate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 4/20 | 0.77 |
| ▸ | SCN2A known ✓ | Q99250 | 4/20 | 0.77 |
| ▸ | SCN3A known ✓ | Q9NY46 | 4/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.77 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.77 |
| ▸ | TSHR | P16473 | 3/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.77 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.77 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.77 |
| ▸ | RAD52 | P43351 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HTR3A | P46098 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benoxinate SCHEMBL30849863 | 0.88 | CYP2D6 (1.00) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Benoxinate SCHEMBL25087 | 0.88 | CYP2D6 (1.00) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Benoxinate SCHEMBL1649661 | 0.87 | RAD52 (1.00) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Benoxinate SCHEMBL212440 | 0.87 | RAD52 (1.00) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Procaine SCHEMBL18741023 | 0.86 | CYP2D6 (0.69) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Benoxinate SCHEMBL16633604 | 0.86 | CYP2D6 (0.91) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Benoxinate SCHEMBL15532182 | 0.86 | CYP2D6 (0.95) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Benoxinate SCHEMBL18740891 | 0.85 | CYP2D6 (0.89) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| SCHEMBL13439964 | 0.83 | CYP2D6 (0.89) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| SCHEMBL10533525 | 0.82 | CYP2D6 (0.83) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180297966-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME | INNOVATIVE ANESTHETICS, LLC | 2018-10-18 | — | — | US | claimed |
| WO-2017066787-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME | LEBEDYEVA IRYNA O (US) | 2017-04-20 | — | — | WO | claimed |
| US-20180297966-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME | INNOVATIVE ANESTHETICS, LLC | 2018-10-18 | — | — | US | disclosed |
| WO-2017066787-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME | LEBEDYEVA IRYNA O (US) | 2017-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180297966-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME | TRPA1, TRPV1, AQP1 | SCN1A 444/4885SCN2A 826/4885SCN3A 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.