Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALPG | P10696 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1554049 | 0.75 | ALDH1A1 (0.42) | MAPK9MAPK10LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5655555 | 0.74 | L3MBTL1 (0.51) | LMNASMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL5655425 | 0.72 | ALDH1A1 (0.48) | LMNASMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL28239177 | 0.70 | GAA (0.43) | MAPK9MAPK10LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10370952 | 0.70 | ALDH1A1 (0.49) | LMNASMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL2958337 | 0.70 | MAPK9 (0.47) | MAPK9MAPK10LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2883560 | 0.69 | MAPK10 (1.00) | MAPK9MAPK10LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL1508006 | 0.69 | ALDH1A1 (0.70) | LMNASMN1; SMN2ALDH1A1GAAALPG | |
| SCHEMBL4041839 | 0.69 | SCN9A (0.37) | MAPK10LMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL10094582 | 0.68 | MAPK9 (0.43) | MAPK9MAPK10LMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1832584-B1 | PYRIMIDINYLISOXAZOLE DERIVATIVE | ASKA PHARM CO LTD (JP) | 2011-12-21 | — | — | EP | disclosed |
| US-7939536-B2 | 5-[(2-chlorophenyl)acetylamino]-3-(4-fluorophenyl)-4-(4-pyrimidinyl)isoxazole; p 38MAP kinase inhibitor; tumor necrosis factor, interleukin, or cyclooxygenase-II related diseases; antiinflammatory, anticarcinogenic, antidiabetic agent | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2011-05-10 | — | — | US | disclosed |
| US-20080114003-A1 | Pyrimidinylisoxazole Derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-15 | — | — | US | disclosed |
| EP-1832584-A1 | PYRIMIDINYLISOXAZOL DERIVATIVE | ASKA Pharmaceutical Co., Ltd. (JP) | 2007-09-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114003-A1 | Pyrimidinylisoxazole Derivatives | MAPK3, MAPK7, MAP3K7 | MAPK9 20/4885MAPK10 51/4885LMNA 4318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.