Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | RAPGEF3 | O95398 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.38 |
| ▸ | ALB | P02768 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | POLG | P54098 | 2/20 | 0.36 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18744137 | 0.85 | LMNA (0.50) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL13176571 | 0.85 | LMNA (0.50) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL19954155 | 0.74 | STING1 (0.57) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL16561105 | 0.74 | STING1 (0.57) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL1331888 | 0.74 | STING1 (0.57) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL17826621 | 0.73 | LMNA (0.47) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL18720751 | 0.73 | LMNA (0.47) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL21107722 | 0.72 | PDE3A (0.49) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL13271029 | 0.72 | LMNA (0.60) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL15259211 | 0.71 | PDE3A (0.43) | LMNATHRBMTORMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624249-B2 | Nucleoside kinase bypass compositions and methods | MERCK SHARP & DOHME CORP. (US) | 2017-04-18 | — | — | US | disclosed |