Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | RAPGEF3 | O95398 | 3/20 | 0.48 |
| ▸ | STING1 | Q86WV6 | 6/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13176571 | 1.00 | LMNA (0.50) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL1331888 | 0.88 | STING1 (0.57) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL19954155 | 0.88 | STING1 (0.57) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL16561105 | 0.88 | STING1 (0.57) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL17826621 | 0.87 | LMNA (0.47) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL18744120 | 0.85 | LMNA (0.39) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL18720751 | 0.84 | LMNA (0.47) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL18742090 | 0.82 | LMNA (0.43) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL30847445 | 0.81 | STING1 (0.54) | LMNARAPGEF3STING1PDE3BPDE3A | |
| SCHEMBL15259214 | 0.81 | LMNA (0.52) | LMNATHRBMTORMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624249-B2 | Nucleoside kinase bypass compositions and methods | MERCK SHARP & DOHME CORP. (US) | 2017-04-18 | — | — | US | disclosed |