Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | RAB9A | P51151 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.57 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.56 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 3/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18745408 | 0.89 | HPSE (0.57) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL15472303 | 0.89 | NR1H4 (0.66) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL3678321 | 0.89 | NPC1 (0.71) | NPC1RAB9AKCNK3KCNK9MAPT | |
| SCHEMBL15472305 | 0.88 | CYP1A2 (0.62) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL18745399 | 0.88 | RXFP1 (0.67) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL13192836 | 0.88 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL18745404 | 0.87 | MEN1 (0.55) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL15472312 | 0.85 | THRB (0.53) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL19860068 | 0.85 | NR1H4 (0.64) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL18745403 | 0.84 | KMT2A (0.59) | NPC1RAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624239-B2 | Protein kinase inhibitors | PHARMASCIENCE INC. (CA) | 2017-04-18 | — | — | US | disclosed |