Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 13/20 | 0.47 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3416768 | 0.86 | CHEK2 (0.61) | CHEK2PKN1PKN2 | |
| SCHEMBL30732472 | 0.83 | CHEK2 (0.47) | CHEK2PKN1PKN2MMP2MMP13 | |
| SCHEMBL22121440 | 0.83 | FABP6 (0.51) | CHEK2PKN1PKN2MMP2MMP13 | |
| SCHEMBL6680675 | 0.83 | F2 (0.51) | — | |
| SCHEMBL9304008 | 0.81 | CHEK2 (0.49) | CHEK2PKN1PKN2MMP2MMP13 | |
| SCHEMBL8262964 | 0.81 | HSP90AA1 (0.55) | CHEK2PKN1PKN2MMP2MMP13 | |
| SCHEMBL16318609 | 0.81 | CHEK2 (0.49) | CHEK2PKN1PKN2MMP2MMP13 | |
| SCHEMBL16134556 | 0.81 | CHEK2 (0.46) | CHEK2PKN1PKN2MMP2MMP13 | |
| SCHEMBL9028459 | 0.80 | F10 (0.55) | CHEK2PKN1PKN2MMP2MMP13 | |
| SCHEMBL10468388 | 0.80 | ALDH1A1 (0.36) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9622991-B2 | Hematopoietic growth factor mimetic small molecule compounds and their uses | LIGAND PHARMACEUTICALS INC. (US) | 2017-04-18 | — | — | US | disclosed |