Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18754179 | 0.86 | KCNH2 (0.37) | CYP19A1CYP1A2CYP3A4TSHRNFKB1 | |
| SCHEMBL18754183 | 0.78 | MCHR1 (0.36) | — | |
| SCHEMBL5114907 | 0.75 | CA2 (0.59) | CA2CYP19A1CYP1A2CYP3A4HTT | |
| SCHEMBL3057081 | 0.72 | CYP1A2 (0.57) | CYP19A1CYP1A2CYP3A4TSHRNFKB1 | |
| SCHEMBL18754199 | 0.72 | AR (0.40) | TSHRHTTALDH1A1 | |
| SCHEMBL27545972 | 0.71 | KMT2A (0.50) | NR3C1NR3C2CYP1A2CYP3A4GAA | |
| SCHEMBL16114691 | 0.71 | MAPT (0.49) | GAAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL21189845 | 0.68 | CYP19A1 (0.38) | CYP19A1CYP3A4ALOX15SMN1; SMN2 | |
| SCHEMBL18938247 | 0.68 | PDE4A (0.37) | ALOX15GAAHTTALDH1A1 | |
| SCHEMBL20244887 | 0.67 | MAOB (0.45) | CYP1A2ALOX12GAASMN1; SMN2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2978754-B1 | BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2017-05-10 | — | — | EP | disclosed |
| EP-2978747-B1 | BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2017-04-19 | — | — | EP | disclosed |