Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | PPID | Q08752 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28722878 | 0.86 | HTT (0.53) | HTTHPGDGLAPKMNLRP3 | |
| SCHEMBL8280364 | 0.85 | GLA (0.63) | HPGDGLAPKMALDH1A1SMN1; SMN2 | |
| SCHEMBL11161449 | 0.83 | HPGD (0.57) | HTTHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL13376876 | 0.82 | POLB (0.46) | HTTHPGDGLAPKMALDH1A1 | |
| SCHEMBL8744812 | 0.79 | SMN1; SMN2 (0.63) | HTTNLRP3ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL17844004 | 0.79 | NLRP3 (0.55) | HTTHPGDNLRP3ALDH1A1SMN1; SMN2 | |
| SCHEMBL4155966 | 0.78 | ALDH1A1 (0.61) | HPGDALDH1A1RAB9A | |
| SCHEMBL2563949 | 0.78 | KMT2A (0.57) | HTTGLAALDH1A1NPC1RAB9A | |
| SCHEMBL4994139 | 0.76 | ALDH1A1 (0.59) | HPGDALDH1A1MAPT | |
| SCHEMBL10898232 | 0.76 | MEN1 (0.72) | HPGDGLAALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2727912-B1 | CRYSTALS OF GLYCINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | TORAY INDUSTRIES (JP) | 2017-04-19 | — | — | EP | disclosed |