Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PPID | Q08752 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1429298 | 0.82 | AKR1B1 (0.55) | SMN1; SMN2HTTMAPK1NLRP3KMT2A | |
| Ammonia Solution, Strong SCHEMBL27532390 | 0.81 | AKR1B1 (0.53) | SMN1; SMN2HTTMAPK1NLRP3KMT2A | |
| SCHEMBL11305630 | 0.80 | NLRP3 (0.52) | SMN1; SMN2HTTMAPK1NLRP3KMT2A | |
| SCHEMBL4003642 | 0.80 | HTT (0.55) | SMN1; SMN2HTTNLRP3KMT2APPID | |
| SCHEMBL18754170 | 0.79 | HTT (0.60) | SMN1; SMN2HTTNLRP3PPIDALDH1A1 | |
| SCHEMBL8744765 | 0.78 | AKR1B1 (0.63) | SMN1; SMN2MAPK1P2RX7KMT2AMEN1 | |
| SCHEMBL30385493 | 0.77 | PPID (0.66) | KMT2AGAAPPIDMEN1ALDH1A1 | |
| SCHEMBL8744815 | 0.76 | GAA (0.56) | HTTP2RX7KMT2AGAAMEN1 | |
| SCHEMBL9594560 | 0.75 | KMT2A (0.47) | SMN1; SMN2HTTMAPK1NLRP3P2RX7 | |
| SCHEMBL8744777 | 0.75 | KMT2A (0.47) | SMN1; SMN2HTTMAPK1NLRP3P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |