Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | THRA | P10827 | 3/20 | 0.56 |
| ▸ | THRB | P10828 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SPHK1 | Q9NYA1 | 8/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5546226 | 0.91 | POLB (0.66) | POLBTHRATHRBHPGDSPHK1 | |
| SCHEMBL3027338 | 0.89 | THRA (0.68) | POLBTHRATHRBSPHK1CA12 | |
| SCHEMBL11297385 | 0.89 | THRA (0.68) | POLBTHRATHRBSPHK1CA12 | |
| SCHEMBL6746649 | 0.89 | THRA (0.68) | POLBTHRATHRBSPHK1CA12 | |
| SCHEMBL2748237 | 0.86 | POLB (0.73) | POLBTHRATHRBALDH1A1HPGD | |
| SCHEMBL20799661 | 0.85 | THRA (0.52) | POLBTHRATHRBALDH1A1HPGD | |
| SCHEMBL22299245 | 0.85 | ENPP2 (0.60) | THRATHRBHPGDCA1CA2 | |
| SCHEMBL22299138 | 0.85 | ENPP2 (0.60) | THRATHRBHPGDCA1CA2 | |
| SCHEMBL22299144 | 0.85 | ENPP2 (0.60) | THRATHRBHPGDCA1CA2 | |
| SCHEMBL10931913 | 0.84 | SPHK1 (0.58) | THRATHRBALDH1A1SPHK1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651913-B1 | INDENO-FUSED RING COMPOUNDS HAVING PHOTOCHROMIC PROPERTIES | TRANSITIONS OPTICAL INC (US) | 2017-04-19 | — | — | EP | disclosed |