Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6659978 | 0.96 | ESR1 (0.32) | ESR1ESR2CYP3A4TDP1 | |
| Hydrochloric Acid SCHEMBL6251721 | 0.88 | TDP1 (0.38) | ESR1ESR2CYP3A4TDP1 | |
| Hydrochloric Acid SCHEMBL678340 | 0.88 | TDP1 (0.38) | ESR1ESR2CYP3A4TDP1 | |
| SCHEMBL3943019 | 0.85 | PCSK9 (0.35) | ESR1ESR2CYP3A4TDP1 | |
| Hydrochloric Acid SCHEMBL27990220 | 0.84 | TDP1 (0.38) | ESR1ESR2CYP3A4TDP1 | |
| Hydrochloric Acid SCHEMBL5591121 | 0.84 | TDP1 (0.38) | ESR1ESR2CYP3A4TDP1 | |
| SCHEMBL163845 | 0.84 | TDP1 (0.41) | ESR1ESR2CYP3A4TDP1 | |
| SCHEMBL372344 | 0.84 | PCSK9 (0.34) | TDP1 | |
| SCHEMBL5921753 | 0.82 | TDP1 (0.39) | ESR1ESR2CYP3A4TDP1 | |
| SCHEMBL3997009 | 0.82 | TDP1 (0.39) | ESR1ESR2CYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10421767-B2 | Aminosilane-functionalized dienes for use in functionalization of elastomeric polymers | TRINSEO EUROPE GMBH (CH) | 2019-09-24 | — | — | US | disclosed |
| US-20180291041-A1 | Aminosilane-Functionalized Dienes for Use in Functionalization of Elastomeric Polymers | TRINSEO EUROPE GMBH (CH) | 2018-10-11 | — | — | US | disclosed |
| EP-3159346-B1 | AMINOSILANE-FUNCTIONALIZED DIENES FOR USE IN FUNCTIONALIZATION OF ELASTOMERIC POLYMERS | TRINSEO EUROPE GMBH (CH) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017067877-A1 | AMINOSILANE-FUNCTIONALIZED DIENES FOR USE IN FUNCTIONALIZATION OF ELASTOMERIC POLYMERS | TRINSEO EUROPE GMBH (CH) | 2017-04-27 | — | — | WO | disclosed |
| EP-3159346-A1 | AMINOSILANE-FUNCTIONALIZED DIENES FOR USE IN FUNCTIONALIZATION OF ELASTOMERIC POLYMERS | Trinseo Europe GmbH (CH) | 2017-04-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10421767-B2 | Aminosilane-functionalized dienes for use in functionalization of elastomeric polymers | PRMT3, CCNL2, SRRM2 | ESR1 473/4885ESR2 256/4885CYP3A4 3049/4885 |
| US-20180291041-A1 | Aminosilane-Functionalized Dienes for Use in Functionalization of Elastomeric Polymers | PRMT3, CCNL2, SRRM2 | ESR1 473/4885ESR2 256/4885CYP3A4 3049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.