SCHEMBL187631

SCHEMBL187631

CCCCOC([SiH2])OCCCC

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.41
ADRB1 P08588 1/20 0.41
ADRB3 P13945 1/20 0.41
DNM1 Q05193 1/20 0.39
TSHR P16473 4/20 0.36
CYP3A4 P08684 3/20 0.36
ALDH1A1 P00352 2/20 0.35
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
LMNA P02545 1/20 0.33
ATM Q13315 1/20 0.32
THRB P10828 1/20 0.32
CNR1 P21554 1/20 0.31
CNR2 P34972 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL188016 0.81 HSD17B10 (0.32) THRB
SCHEMBL8347145 0.77 ADRB2 (0.41) ADRB2ADRB1ADRB3DNM1TSHR
SCHEMBL338812 0.75 ADRB2 (0.45) ADRB2ADRB1ADRB3DNM1TSHR
SCHEMBL9393419 0.75 ADRB2 (0.45) ADRB2ADRB1ADRB3DNM1TSHR
SCHEMBL20995918 0.74 ADRB2 (0.39) ADRB2ADRB1ADRB3DNM1TSHR
SCHEMBL115527 0.73 LMNA (0.47) ADRB2ADRB1ADRB3DNM1TSHR
SCHEMBL126499 0.73
SCHEMBL2370199 0.73
SCHEMBL31296291 0.72 ADRB2 (0.38) ADRB2ADRB1ADRB3DNM1TSHR
SCHEMBL3752167 0.72 ADRB2 (0.38) ADRB2ADRB1ADRB3DNM1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1719799-B1 Run flat tire SUMITOMO RUBBER IND (JP) 2012-01-04 EP disclosed
EP-1398353-B1 THERMOPLASTIC RESIN COMPOSITION KANEKA CORP (JP) 2010-10-13 EP disclosed
US-7405256-B2 Side reinforcing layer in which low exothermic property and high hardness are compatible and durability is improved; carbon black of specified absorption, natural ore such as sericite, a conjugated diene polymer modified with alkoxysilyl and primary amine groups, and coupled with bifunctional monomers SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2008-07-29 US disclosed
US-7282535-B2 Thermoplastic resin composition KANEKA CORPORATION (JP) 2007-10-16 US disclosed
EP-1719799-A1 Run flat tire Sumitomo Rubber Industries, Ltd. (JP) 2006-11-08 EP disclosed
US-20060247365-A1 Side reinforcing layer in which low exothermic property and high hardness are compatible and durability is improved; carbon black of specified absorption, natural ore such as sericite, a conjugated diene polymer modified with alkoxysilyl and primary amine groups, and coupled with bifunctional monomers SUMITOMO RUBBER INDUSTRIES, LTD. 2006-11-02 US disclosed
US-20050004318-A1 Curable composition OHSHIRO NOBUAKI (JP) 2005-01-06 US disclosed
EP-1452550-A1 CURABLE COMPOSITION KANEKA CORPORATION (JP) 2004-09-01 EP disclosed
US-20040147674-A1 Thermoplastic resin composition KANEKA CORPORATION (JP) 2004-07-29 US disclosed
EP-1398353-A1 THERMOPLASTIC RESIN COMPOSITION Kaneka Corporation (JP) 2004-03-17 EP disclosed