Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20136961 | 0.90 | TP53 (0.61) | TDP1TP53IDO1HSD17B1HSD17B2 | |
| SCHEMBL14363365 | 0.85 | TRPA1 (0.62) | TDP1TP53IDO1TRPA1BACE1 | |
| SCHEMBL4366753 | 0.85 | BACE1 (0.59) | TDP1TP53IDO1TRPA1BACE1 | |
| SCHEMBL30538128 | 0.85 | BACE1 (0.59) | TDP1TP53IDO1TRPA1BACE1 | |
| SCHEMBL17753396 | 0.83 | TLR8 (0.60) | TDP1TP53HSD17B1HSD17B2TLR8 | |
| SCHEMBL6847806 | 0.82 | TRPA1 (0.56) | TDP1TP53IDO1TRPA1BACE1 | |
| SCHEMBL29941912 | 0.82 | TRPA1 (0.56) | TDP1TP53IDO1TRPA1BACE1 | |
| SCHEMBL28962661 | 0.81 | TP53 (0.61) | TDP1TP53HSD17B1HSD17B2TRPA1 | |
| SCHEMBL14363399 | 0.81 | BACE1 (0.51) | TDP1TP53IDO1TRPA1ESR2 | |
| SCHEMBL3559333 | 0.80 | TP53 (0.65) | TDP1TP53HSD17B1HSD17B2TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108430463-B | Improved synthesis of honokiol | 高露洁-棕榄公司 | 2021-01-29 | — | — | CN | disclosed |
| EP-3364957-B1 | IMPROVED SYNTHESIS OF HONOKIOL | COLGATE PALMOLIVE CO (US) | 2020-12-09 | — | — | EP | disclosed |
| EP-3364957-B1 | IMPROVED SYNTHESIS OF HONOKIOL | COLGATE PALMOLIVE CO (US) | 2020-12-09 | — | — | EP | disclosed |
| EP-3364957-A1 | IMPROVED SYNTHESIS OF HONOKIOL | Colgate-Palmolive Company (US) | 2018-08-29 | — | — | EP | disclosed |
| EP-3364957-A1 | IMPROVED SYNTHESIS OF HONOKIOL | Colgate-Palmolive Company (US) | 2018-08-29 | — | — | EP | disclosed |
| US-10053406-B2 | Synthesis of honokiol | COLGATE-PALMOLIVE COMPANY (US) | 2018-08-21 | — | — | US | disclosed |
| US-10053406-B2 | Synthesis of honokiol | COLGATE-PALMOLIVE COMPANY (US) | 2018-08-21 | — | — | US | disclosed |
| US-20180134737-A1 | MITO-HONOKIOL COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF | THE MEDICAL COLLEGE OF WISCONSIN, INC. | 2018-05-17 | — | — | US | disclosed |
| WO-2017070568-A1 | IMPROVED SYNTHESIS OF HONOKIOL | COLGATE-PALMOLIVE COMPANY (US) | 2017-04-27 | — | — | WO | disclosed |
| WO-2017070568-A1 | IMPROVED SYNTHESIS OF HONOKIOL | COLGATE-PALMOLIVE COMPANY (US) | 2017-04-27 | — | — | WO | disclosed |
| WO-2017070568-A1 | IMPROVED SYNTHESIS OF HONOKIOL | COLGATE-PALMOLIVE COMPANY (US) | 2017-04-27 | — | — | WO | disclosed |
| US-20170113989-A1 | SYNTHESIS OF HONOKIOL | COLGATE-PALMOLIVE COMPANY | 2017-04-27 | — | — | US | disclosed |
| US-20170113989-A1 | SYNTHESIS OF HONOKIOL | COLGATE-PALMOLIVE COMPANY | 2017-04-27 | — | — | US | disclosed |
| US-20170113989-A1 | SYNTHESIS OF HONOKIOL | COLGATE-PALMOLIVE COMPANY | 2017-04-27 | — | — | US | disclosed |
| US-20170113989-A1 | SYNTHESIS OF HONOKIOL | COLGATE-PALMOLIVE COMPANY | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170113989-A1 | SYNTHESIS OF HONOKIOL | UGT2B7, UGT1A7, DHCR7 | TDP1 1575/4885TP53 3126/4885IDO1 2931/4885 |
| US-10053406-B2 | Synthesis of honokiol | UGT2B7, UGT1A7, DHCR7 | TDP1 1575/4885TP53 3126/4885IDO1 2931/4885 |
| US-20180134737-A1 | MITO-HONOKIOL COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF | MFN2, MT-ND2, PCK2 | TDP1 2249/4885TP53 300/4885IDO1 2709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.