Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18785277 | 1.00 | CHRM2 (0.43) | CHRM2CHRM3OPRM1SIGMAR1KCNH2 | |
| SCHEMBL18766506 | 1.00 | CHRM2 (0.43) | CHRM2CHRM3OPRM1SIGMAR1KCNH2 | |
| SCHEMBL18766520 | 1.00 | CHRM2 (0.43) | CHRM2CHRM3OPRM1SIGMAR1KCNH2 | |
| SCHEMBL17318795 | 0.96 | CHRM2 (0.46) | CHRM2CHRM3OPRM1SIGMAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL19096857 | 0.95 | CHRM2 (0.45) | CHRM2CHRM3OPRM1SIGMAR1KCNH2 | |
| SCHEMBL18785265 | 0.86 | CHRM2 (0.44) | CHRM2CHRM3OPRM1SIGMAR1KCNH2 | |
| SCHEMBL18766550 | 0.86 | CHRM2 (0.44) | CHRM2CHRM3OPRM1SIGMAR1KCNH2 | |
| SCHEMBL18766497 | 0.86 | CHRM2 (0.44) | CHRM2CHRM3OPRM1SIGMAR1KCNH2 | |
| SCHEMBL19096868 | 0.84 | CHRM2 (0.43) | CHRM2CHRM3OPRM1SIGMAR1KCNH2 | |
| SCHEMBL20621644 | 0.84 | CHRM2 (0.59) | CHRM2CHRM3CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10689398-B2 | OXA-Diazaspiro compounds having activity against pain | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-06-23 | — | — | US | claimed |
| US-20190002475-A1 | OXA-DIAZASPIRO COMPOUNDS HAVING ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-01-03 | — | — | US | claimed |
| US-10689398-B2 | OXA-Diazaspiro compounds having activity against pain | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-06-23 | — | — | US | disclosed |
| US-10689398-B2 | OXA-Diazaspiro compounds having activity against pain | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-06-23 | — | — | US | disclosed |
| US-20190002475-A1 | OXA-DIAZASPIRO COMPOUNDS HAVING ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-01-03 | — | — | US | disclosed |
| US-20190002475-A1 | OXA-DIAZASPIRO COMPOUNDS HAVING ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-01-03 | — | — | US | disclosed |
| EP-3365346-A1 | OXA-DIAZASPIRO COMPOUNDS HAVING ACTIVITY AGAINST PAIN | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2018-08-29 | — | — | EP | disclosed |
| WO-2017067664-A1 | OXA-DIAZASPIRO COMPOUNDS HAVING ACTIVITY AGAINST PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2017-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10689398-B2 | OXA-Diazaspiro compounds having activity against pain | OPRD1, SIGMAR1, OPRK1 | CHRM2 1069/4885CHRM3 332/4885OPRM1 5/4885 |
| US-20190002475-A1 | OXA-DIAZASPIRO COMPOUNDS HAVING ACTIVITY AGAINST PAIN | OPRD1, SIGMAR1, OPRK1 | CHRM2 1069/4885CHRM3 332/4885OPRM1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.