Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768578 | 0.92 | HRH4 (0.46) | HRH4SLC6A2SLC6A4AKR1C3 | |
| SCHEMBL18768580 | 0.89 | HTR1A (0.47) | HRH4SLC6A4 | |
| SCHEMBL18768636 | 0.87 | HRH4 (0.57) | HRH4SLC6A2SLC6A4AKR1C3GRIN2D | |
| SCHEMBL18768437 | 0.85 | AKR1C3 (0.46) | SLC6A2SLC6A4AKR1C3GRIN2DGRIN3B | |
| SCHEMBL18768572 | 0.80 | OPRM1 (0.48) | HRH4SLC6A2SLC6A4AKR1C3 | |
| SCHEMBL18768164 | 0.79 | AKR1C3 (0.42) | SLC6A2SLC6A4AKR1C3AR | |
| SCHEMBL18768557 | 0.78 | HTR1A (0.50) | HRH4SLC6A4 | |
| SCHEMBL18768456 | 0.78 | AKR1C3 (0.42) | SLC6A2SLC6A4AKR1C3AR | |
| SCHEMBL18768434 | 0.78 | — | — | |
| SCHEMBL18768208 | 0.78 | MEN1 (0.43) | AKR1C3AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066705-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES | AQUINNAH PHARMACEUTICALS, INC. (US) | 2017-04-20 | — | — | WO | disclosed |