Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.44 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 4/20 | 0.41 |
| ▸ | LDHB | P07195 | 4/20 | 0.41 |
| ▸ | DDT | P30046 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | CD74 | P04233 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18770665 | 0.88 | GPR119 (0.46) | MAPK1AXLFYN | |
| SCHEMBL18770690 | 0.88 | CDK8 (0.42) | MAP4K4FYN | |
| SCHEMBL18770683 | 0.79 | LDHA (0.40) | MAP4K4LDHALDHBDYRK1BPTGS1 | |
| SCHEMBL27699378 | 0.76 | FYN (0.49) | MAP4K4DDTFYN | |
| SCHEMBL18770694 | 0.71 | GPR119 (0.48) | MAP4K4MAPK1AXL | |
| SCHEMBL16186626 | 0.69 | AXL (0.75) | MAP4K4MAPK1AXLFYN | |
| SCHEMBL19721378 | 0.67 | KMT2A (0.47) | MAP4K4FYN | |
| SCHEMBL19327534 | 0.67 | FGFR1 (0.47) | MAP4K4 | |
| SCHEMBL15359055 | 0.67 | USP7 (0.60) | MAP4K4FYNDYRK1B | |
| SCHEMBL3115615 | 0.66 | CYP1A2 (0.64) | MAP2K4MAPK1MAPKAPK3MAPK6CD74 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3365335-A1 | 2-ARYL- AND 2-HETEROARYL-SUBSTITUTED 2-PYRIDAZIN-3(2H)-ONE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES | Array Biopharma, Inc. (US) | 2018-08-29 | — | — | EP | disclosed |
| WO-2017070708-A1 | 2-ARYL- AND 2-HETEROARYL-SUBSTITUTED 2-PYRIDAZIN-3(2H)-ONE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES | ARRAY BIOPHARMA, INC. (US) | 2017-04-27 | — | — | WO | disclosed |