Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19265579 | 0.89 | TLR8 (0.48) | HPGDL3MBTL1HSD17B10TLR8ROCK2 | |
| SCHEMBL19265449 | 0.87 | TLR8 (0.41) | HPGDL3MBTL1ALDH1A1HSD17B10KMT2A | |
| SCHEMBL19265617 | 0.87 | TLR8 (0.47) | HPGDL3MBTL1HSD17B10TLR8 | |
| SCHEMBL18771727 | 0.86 | TLR8 (0.42) | HPGDL3MBTL1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL19265655 | 0.84 | HPGD (0.35) | HPGDL3MBTL1ALDH1A1POLBCYP2C19 | |
| SCHEMBL19265668 | 0.80 | HPGD (0.41) | HPGDALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL19265647 | 0.78 | PRKCZ (0.37) | L3MBTL1ALDH1A1CYP2C19KMT2AHTT | |
| SCHEMBL19265705 | 0.76 | FDFT1 (0.38) | HPGDL3MBTL1ALDH1A1POLBHSD17B10 | |
| SCHEMBL19265630 | 0.76 | TLR8 (0.36) | HPGDL3MBTL1POLBKMT2AHTT | |
| SCHEMBL18771941 | 0.75 | HPGD (0.41) | HPGDALDH1A1KMT2ASMN1; SMN2TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3207930-A1 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | VentiRx Pharmaceuticals, Inc. (US) | 2017-08-23 | — | — | EP | disclosed |