Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.31 |
| ▸ | STS | P08842 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19265546 | 0.93 | TLR8 (0.33) | TLR8TLR7ERN1LRRK2OTUD7B | |
| SCHEMBL18772124 | 0.92 | TLR8 (0.38) | TLR8TLR7ERN1OTUD7BCYP3A4 | |
| SCHEMBL18772002 | 0.92 | HPGD (0.37) | TLR8TLR7NPC1MAPTRAB9A | |
| SCHEMBL18771963 | 0.87 | MMP2 (0.41) | TLR8TLR7MMP2ALDH1A1HPGD | |
| SCHEMBL18772079 | 0.86 | TLR8 (0.41) | TLR8TLR7 | |
| SCHEMBL18771997 | 0.85 | TLR8 (0.45) | TLR8TLR7MAPTKDM4EALDH1A1 | |
| SCHEMBL18771727 | 0.85 | TLR8 (0.42) | TLR8TLR7NPC1RAB9AKDM4E | |
| SCHEMBL19265705 | 0.85 | FDFT1 (0.38) | TLR8TLR7STSCYP1A2MAPT | |
| SCHEMBL18771974 | 0.82 | MMP2 (0.45) | TLR8TLR7MMP2CYP1A2NPC1 | |
| SCHEMBL19265523 | 0.82 | TLR8 (0.35) | TLR8TLR7MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3159337-A2 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Ventirx Pharmaceuticals, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |