Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | MLYCD | O95822 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18771933 | 0.92 | TLR8 (0.34) | HPGDALDH1A1MAPTTLR8TLR7 | |
| SCHEMBL18771743 | 0.88 | TLR8 (0.43) | HPGDALDH1A1MAPTTLR8TLR7 | |
| SCHEMBL18772079 | 0.87 | TLR8 (0.41) | TLR8TLR7 | |
| SCHEMBL18771963 | 0.86 | MMP2 (0.41) | HPGDALDH1A1TLR8TLR7 | |
| SCHEMBL18771997 | 0.85 | TLR8 (0.45) | HPGDALDH1A1MAPTHRH3LMNA | |
| SCHEMBL19265546 | 0.85 | TLR8 (0.33) | HPGDALDH1A1MAPTTLR8TLR7 | |
| SCHEMBL18771727 | 0.84 | TLR8 (0.42) | HPGDALDH1A1HRH3LMNATSHR | |
| SCHEMBL18772124 | 0.84 | TLR8 (0.38) | HPGDLMNATSHRTLR8TLR7 | |
| SCHEMBL19265705 | 0.84 | FDFT1 (0.38) | HPGDALDH1A1MAPTLMNATLR8 | |
| SCHEMBL18771985 | 0.82 | TLR8 (0.40) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3159337-A2 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Ventirx Pharmaceuticals, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |