Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14445220 | 0.98 | ALDH1A1 (0.56) | ALDH1A1NPSR1CYP2D6TSHRL3MBTL1 | |
| SCHEMBL1879048 | 0.97 | ALDH1A1 (0.50) | ALDH1A1NPSR1CYP2D6TSHRL3MBTL1 | |
| SCHEMBL2073016 | 0.81 | ALDH1A1 (0.45) | ALDH1A1NPSR1CYP2D6TSHRL3MBTL1 | |
| SCHEMBL31547066 | 0.80 | CYP2D6 (0.46) | ALDH1A1NPSR1CYP2D6TSHRL3MBTL1 | |
| SCHEMBL13573000 | 0.80 | CYP2D6 (0.46) | ALDH1A1NPSR1CYP2D6TSHRL3MBTL1 | |
| SCHEMBL4087213 | 0.79 | ALDH1A1 (0.48) | ALDH1A1NPSR1CYP2D6TSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL27351255 | 0.77 | ALDH1A1 (0.47) | ALDH1A1NPSR1CYP2D6TSHRL3MBTL1 | |
| SCHEMBL934442 | 0.77 | ALDH1A1 (0.47) | ALDH1A1NPSR1CYP2D6TSHRL3MBTL1 | |
| SCHEMBL873716 | 0.77 | ALDH1A1 (0.47) | ALDH1A1NPSR1CYP2D6TSHRL3MBTL1 | |
| SCHEMBL26654162 | 0.76 | ALDH1A1 (0.44) | ALDH1A1NPSR1CYP2D6TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2192109-B1 | BICYCLIC -AMINO ACID DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |
| US-7947738-B2 | Bicyclic γ-amino acid derivative | DAIICHI SANKYO COMPANY, LTD. (JP) | 2011-05-24 | — | — | US | disclosed |
| US-20100249229-A1 | BICYCLIC gamma-AMINO ACID DERIVATIVE | DAIICHI SANKYO COMPANY, LTD. (JP) | 2010-09-30 | — | — | US | disclosed |
| EP-2192109-A1 | BICYCLIC -AMINO ACID DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| US-4999451-A | Process for preparing dihalovinylcyclopropanecarboxylates | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-03-12 | — | — | US | disclosed |
| US-4833266-A | Process for preparing dihalovinylcyclopropanecarboxylates | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1989-05-23 | — | — | US | disclosed |
| US-4681953-A | Process for preparing dihalovinylcyclopropanecarboxylates | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1987-07-21 | — | — | US | disclosed |
| US-4454343-A | Intermediates in a process for preparing dihalovinylcyclopropanecarboxylates | FMC CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| US-4214097-A | Process for preparing dihalovinylcyclopropanecarboxylates | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1980-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249229-A1 | BICYCLIC gamma-AMINO ACID DERIVATIVE | GLRA2, GLRB, BCAT1 | ALDH1A1 521/4885NPSR1 396/4885CYP2D6 1150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.