Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17046935 | 0.74 | ALDH1A1 (0.50) | KMT2AMAPTTP53ALDH1A1HTT | |
| SCHEMBL6990818 | 0.73 | CES2 (0.40) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL17108461 | 0.70 | KDM4E (0.49) | KMT2AMAPTTP53ALDH1A1HTT | |
| SCHEMBL17055295 | 0.69 | MAPT (0.51) | KMT2AMAPTTP53ALDH1A1HTT | |
| SCHEMBL17108459 | 0.69 | SMN1; SMN2 (0.43) | KMT2AMAPTTP53ALDH1A1HTT | |
| SCHEMBL17108468 | 0.68 | ALDH1A1 (0.55) | KMT2AMAPTTP53ALDH1A1HTT | |
| SCHEMBL17054745 | 0.66 | ALDH1A1 (0.48) | KMT2AMAPTTP53ALDH1A1HTT | |
| SCHEMBL17055277 | 0.64 | SMN1; SMN2 (0.50) | KMT2AMAPTTP53ALDH1A1HTT | |
| SCHEMBL19174276 | 0.61 | ALDH1A1 (0.38) | KMT2AMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL10203915 | 0.61 | RAB9A (0.44) | KMT2AALDH1A1HTTHRH4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9630970-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2017-04-25 | — | — | US | disclosed |