SCHEMBL18779656

SCHEMBL18779656

C=CC(=C)C[Si](C)(C)N(Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.37
TSHR P16473 1/20 0.37
LMNA P02545 1/20 0.37
GAA P10253 1/20 0.36
AOC3 Q16853 1/20 0.35
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
CA12 O43570 2/20 0.34
CA9 Q16790 2/20 0.34
GSTO1 P78417 1/20 0.34
MGLL Q99685 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20677265 0.72 AOC3 (0.47) ALDH1A1TSHRLMNAGAAAOC3
SCHEMBL6534426 0.71 CARM1 (0.46) ALDH1A1TSHRLMNAGAAAOC3
SCHEMBL19712128 0.70 ALDH1A1 (0.46) ALDH1A1TSHRLMNAAOC3NPC1
SCHEMBL9804706 0.68 TSHR (0.54) ALDH1A1TSHRLMNAAOC3NPC1
SCHEMBL31093195 0.68 HDAC3 (0.44) ALDH1A1TSHRLMNAGAANPC1
Styrene SCHEMBL15142056 0.68 ALDH1A1 (0.50) ALDH1A1TSHRCYP3A4
SCHEMBL20343348 0.68 ALDH1A1 (0.40) ALDH1A1TSHRGAAAOC3NPC1
SCHEMBL28280605 0.67 TSHR (0.48) ALDH1A1TSHRLMNAAOC3NPC1
SCHEMBL1073587 0.67 CES1 (0.46) ALDH1A1TSHRCYP3A4CYP2C9CYP2C19
Benzene SCHEMBL28149238 0.67 CES1 (0.46) ALDH1A1TSHRCYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3159346-A1 AMINOSILANE-FUNCTIONALIZED DIENES FOR USE IN FUNCTIONALIZATION OF ELASTOMERIC POLYMERS Trinseo Europe GmbH (CH) 2017-04-26 EP disclosed