Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.38 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18780327 | 0.86 | BTK (0.54) | BTKALDH1A1MAPTMCL1XDH | |
| SCHEMBL18780323 | 0.85 | BTK (0.52) | BTKMCL1TNK2 | |
| SCHEMBL18780267 | 0.85 | BTK (0.53) | BTKMCL1XDHTNK2NPC1 | |
| SCHEMBL18800897 | 0.84 | ALDH1A1 (0.40) | BTKALDH1A1MAPTMCL1XDH | |
| SCHEMBL18780264 | 0.84 | BTK (0.55) | BTKMCL1TNK2 | |
| SCHEMBL18780265 | 0.83 | BTK (0.52) | BTKMCL1TNK2 | |
| SCHEMBL18780380 | 0.82 | BTK (0.54) | BTKALDH1A1MAPTMCL1XDH | |
| SCHEMBL16168586 | 0.82 | BTK (0.48) | BTKALDH1A1MCL1TNK2 | |
| SCHEMBL18780266 | 0.81 | BTK (0.53) | BTKMCL1XDHTNK2NPC1 | |
| SCHEMBL18780322 | 0.80 | BTK (0.53) | BTKMCL1XDHTNK2GSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789614-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |