Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | ATR | Q13535 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18780323 | 0.92 | BTK (0.52) | BTKTNK2F10MCL1F2 | |
| SCHEMBL16168586 | 0.88 | BTK (0.48) | BTKTNK2F10MCL1PLAU | |
| SCHEMBL18780329 | 0.86 | PLAU (0.53) | BTKATRPLAUF2 | |
| SCHEMBL18780264 | 0.86 | BTK (0.55) | BTKTNK2ATRMCL1 | |
| SCHEMBL18780327 | 0.86 | BTK (0.54) | BTKTNK2F10MCL1F2 | |
| SCHEMBL18780267 | 0.85 | BTK (0.53) | BTKTNK2F10MCL1F2 | |
| SCHEMBL18780383 | 0.84 | NPC1 (0.54) | BTKF10ATRF2 | |
| SCHEMBL18780343 | 0.83 | BTK (0.50) | BTKTNK2MCL1 | |
| SCHEMBL16168567 | 0.82 | BTK (0.55) | BTKTNK2MCL1 | |
| SCHEMBL18780338 | 0.82 | RAB9A (0.50) | BTKF10ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789614-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |