Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | FABP1 | P07148 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18780329 | 0.90 | PLAU (0.53) | BTKPLAUMEN1KMT2AF2 | |
| SCHEMBL18780323 | 0.90 | BTK (0.52) | BTKTNK2MCL1F2F10 | |
| SCHEMBL18780265 | 0.88 | BTK (0.52) | BTKPLAUTNK2MCL1F2 | |
| SCHEMBL18780383 | 0.88 | NPC1 (0.54) | BTKF2F10 | |
| SCHEMBL18780327 | 0.84 | BTK (0.54) | BTKTNK2MCL1MEN1KMT2A | |
| SCHEMBL18780267 | 0.83 | BTK (0.53) | BTKTNK2MCL1MEN1KMT2A | |
| SCHEMBL18780264 | 0.82 | BTK (0.55) | BTKFYNTNK2MCL1KMT2A | |
| SCHEMBL18780343 | 0.82 | BTK (0.50) | BTKTNK2MCL1ALDH1A1 | |
| SCHEMBL18780338 | 0.81 | RAB9A (0.50) | BTKMEN1KMT2AF10ALDH1A1 | |
| SCHEMBL18780380 | 0.81 | BTK (0.54) | BTKMCL1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789614-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |
| EP-2789614-A1 | Azaindazoles as Btk kinase modulators and use thereof | Bristol-Myers Squibb Company (US) | 2014-10-15 | — | — | EP | disclosed |