Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL18784513 | 0.97 | PTPN1 (0.41) | PTPN1ATMERAP1HTTBCHE | |
| Fluoride Ion SCHEMBL18784475 | 0.97 | PTPN1 (0.38) | PTPN1ATMERAP1HTTBCHE | |
| Bromide SCHEMBL19095358 | 0.97 | ATM (0.41) | PTPN1ATMERAP1HTTBCHE | |
| SCHEMBL18784533 | 0.94 | SMN1; SMN2 (0.37) | PTPN1ATMERAP1HTTBCHE | |
| SCHEMBL18784614 | 0.89 | LMNA (0.38) | PTPN1ATMHTTBCHEACHE | |
| Trifluoromethanesulfonic Acid SCHEMBL18784542 | 0.87 | KCNH2 (0.41) | ATMHTTACHEPOLBSMN1; SMN2 | |
| SCHEMBL18784436 | 0.85 | LMNA (0.49) | ATMHTTACHEALDH1A1KDM4E | |
| SCHEMBL18784458 | 0.84 | LMNA (0.40) | ATMHTTACHEALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL18784392 | 0.83 | CYP19A1 (0.41) | CYP1A2ALDH1A1KDM4EAPOBEC3AAPOBEC3G | |
| SCHEMBL17378576 | 0.81 | ALDH1A1 (0.37) | PTPN1HTTCYP1A2CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3162799-B1 | FLUOROALKYLATING AGENT | KUMIAI CHEMICAL INDUSTRY CO (JP) | 2021-03-10 | — | — | EP | disclosed |
| US-10696640-B2 | Fluoroalkylating agent | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2020-06-30 | — | — | US | disclosed |
| US-20190233380-A1 | FLUOROALKYLATING AGENT | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2019-08-01 | — | — | US | disclosed |
| US-10308613-B2 | Fluoroalkylating agent | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2019-06-04 | — | — | US | disclosed |
| US-20170197920-A1 | FLUOROALKYLATING AGENT | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2017-07-13 | — | — | US | disclosed |
| EP-3162799-A1 | FLUOROALKYLATING AGENT | Ihara Chemical Industry Co., Ltd. (JP) | 2017-05-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308613-B2 | Fluoroalkylating agent | AFF1, AFF4, AFF2 | ACHE 1910/4885PTPN1 2066/4885ATM 2573/4885 |
| US-10696640-B2 | Fluoroalkylating agent | AFF1, AFF4, AFF2 | ACHE 1910/4885PTPN1 2066/4885ATM 2573/4885 |
| US-20190233380-A1 | FLUOROALKYLATING AGENT | AFF1, AFF4, AFF2 | ACHE 1910/4885PTPN1 2066/4885ATM 2573/4885 |
| US-20170197920-A1 | FLUOROALKYLATING AGENT | AFF1, AFF4, AFF2 | ACHE 1910/4885PTPN1 2066/4885ATM 2573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.