Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 19/20 | 0.76 |
| ▸ | ADORA1 | P30542 | 18/20 | 0.76 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12636237 | 0.91 | ADORA2A (0.65) | ADORA2AADORA1ADORA2BADORA3HRH3 | |
| SCHEMBL8071160 | 0.86 | ADORA2A (1.00) | ADORA2AADORA1ADORA2BADORA3HRH3 | |
| SCHEMBL1883908 | 0.83 | ADORA2A (0.70) | ADORA2AADORA1ADORA2BADORA3HRH3 | |
| SCHEMBL1882427 | 0.80 | ADORA2A (0.57) | ADORA2AADORA1ADORA2BADORA3HRH3 | |
| SCHEMBL1830502 | 0.79 | ADORA2A (1.00) | ADORA2AADORA1ADORA2BADORA3HRH3 | |
| SCHEMBL1883877 | 0.77 | ADORA2A (0.60) | ADORA2AADORA1 | |
| SCHEMBL1877251 | 0.76 | ADORA2A (0.58) | ADORA2AADORA1ADORA2BHRH3 | |
| SCHEMBL1880042 | 0.75 | ADORA2A (0.57) | ADORA2AADORA1ADORA2BHRH3 | |
| SCHEMBL1885220 | 0.75 | ADORA2A (0.62) | ADORA2AADORA1 | |
| SCHEMBL6857591 | 0.75 | ADORA1 (0.65) | ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105492-A1 | ARYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | US | disclosed |
| US-20110105492-A1 | ARYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | US | disclosed |
| US-20110105492-A1 | ARYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105492-A1 | ARYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS | ADORA2A, ADORA3, ADORA2B | ADORA2A 1/4885ADORA1 4/4885ADORA2B 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.