Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.67 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31061131 | 0.80 | HRH3 (1.00) | HRH3CHRNA7HRH4SLC6A3HTR2A | |
| SCHEMBL10508496 | 0.79 | HRH3 (0.97) | HRH3CHRNA7HRH4SLC6A3HTR2A | |
| SCHEMBL694595 | 0.74 | ADORA1 (0.39) | HRH3CHRNA7MEN1MPO | |
| SCHEMBL5178946 | 0.74 | MTNR1A (0.36) | HRH3CHRNA7 | |
| SCHEMBL8485537 | 0.73 | HRH3 (0.62) | HRH3CHRNA7HRH4MEN1SLC6A3 | |
| SCHEMBL23482001 | 0.72 | HRH3 (0.60) | HRH3CHRNA7MEN1DRD2 | |
| SCHEMBL5778675 | 0.72 | RHEB (0.37) | HRH3 | |
| SCHEMBL188218 | 0.71 | GAA (0.35) | HRH3HTR2AHTR2C | |
| SCHEMBL1662293 | 0.71 | CYP1A2 (0.41) | — | |
| SCHEMBL2562389 | 0.71 | RHEB (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401281-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | MSD K.K. (JP) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010098367-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-02 | — | — | WO | disclosed |