Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 6/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR1D | P28221 | 2/20 | 0.33 |
| ▸ | HTR1E | P28566 | 2/20 | 0.33 |
| ▸ | HTR5A | P47898 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL694595 | 0.81 | ADORA1 (0.39) | GAAMTNR1AMTNR1BLOXL2HRH3 | |
| SCHEMBL5178946 | 0.78 | MTNR1A (0.36) | MTNR1AMTNR1BLOXL2HRH3 | |
| SCHEMBL8570896 | 0.78 | LOXL2 (0.55) | HTR6HTR2CMTNR1AMTNR1BLOXL2 | |
| SCHEMBL189125 | 0.78 | LOXL2 (0.37) | MTNR1AMTNR1BLOXL2 | |
| SCHEMBL5778675 | 0.75 | RHEB (0.37) | MTNR1AMTNR1BLOXL2HRH3 | |
| SCHEMBL5778097 | 0.75 | DAO (0.39) | MTNR1AMTNR1BLOXL2HRH3 | |
| SCHEMBL1662293 | 0.74 | CYP1A2 (0.41) | MTNR1AMTNR1B | |
| SCHEMBL28546347 | 0.74 | HTR2A (0.50) | HTR1AHTR2AHTR2CMTNR1AMTNR1B | |
| SCHEMBL2562389 | 0.74 | RHEB (0.36) | MTNR1AMTNR1BLOXL2 | |
| SCHEMBL4563834 | 0.72 | LOXL2 (0.63) | HTR6HTR7HTR1AHTR1DHTR1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401281-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | MSD K.K. (JP) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010098367-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-02 | — | — | WO | disclosed |