Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 3/20 | 0.43 |
| ▸ | CDK8 | P49336 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13674910 | 0.80 | NOTUM (0.51) | NOTUMCCNCCDK8ALDH1A1MAPT | |
| SCHEMBL1127328 | 0.80 | NOTUM (0.70) | NOTUMCCNCCDK8ALDH1A1MAPT | |
| SCHEMBL30471697 | 0.77 | CCNC (0.69) | NOTUMCCNCCDK8ALDH1A1MAPT | |
| SCHEMBL4140356 | 0.76 | ALDH1A1 (0.56) | NOTUMCCNCCDK8ALDH1A1MAPT | |
| SCHEMBL14226740 | 0.73 | KMO (0.60) | MAPTKMODHODHSMN1; SMN2 | |
| SCHEMBL1126817 | 0.72 | GABRP (0.54) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL10940124 | 0.72 | NOTUM (0.46) | NOTUMCCNCCDK8ALDH1A1MAPT | |
| Biphenyl SCHEMBL2472693 | 0.70 | CYP2C9 (0.54) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL8237871 | 0.70 | SMN1; SMN2 (0.59) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL13246765 | 0.70 | SMN1; SMN2 (0.59) | ALDH1A1MAPTMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9815784-B2 | CC-1065 analogs and their conjugates | SYNTARGA B.V. (NL) | 2017-11-14 | — | — | US | disclosed |
| US-9629924-B2 | Conjugates of CC-1065 analogs and bifunctional linkers | SYNTARGA BV (NL) | 2017-04-25 | — | — | US | disclosed |