Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 9/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.47 |
| ▸ | PIM1 | P11309 | 5/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25237071 | 0.85 | PTPN11 (0.38) | PRKCQPRKCDPIM1HDAC1TLR9 | |
| SCHEMBL25237145 | 0.85 | PTPN11 (0.38) | PRKCQPRKCDPIM1HDAC1TLR9 | |
| Hydrochloric Acid SCHEMBL25283147 | 0.83 | PTPN11 (0.37) | PRKCQPRKCDPIM1HDAC1TLR9 | |
| SCHEMBL4436043 | 0.79 | PIM1 (0.53) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL4436036 | 0.79 | PIM1 (0.53) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL3272049 | 0.77 | HTR3E (0.62) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL29675442 | 0.77 | PRKCQ (0.46) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL29675748 | 0.77 | PRKCQ (0.46) | PRKCQPRKCDPIM1PIM3PIM2 | |
| Hydrochloric Acid SCHEMBL9130628 | 0.76 | HTR3E (0.60) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL18765491 | 0.74 | HTR3A (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017068412-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-04-27 | — | — | WO | disclosed |