Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.53 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.53 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.53 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | KHK | P50053 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436036 | 1.00 | PIM1 (0.53) | PIM1PIM3PIM2HTR3EHTR3B | |
| SCHEMBL3272049 | 0.83 | HTR3E (0.62) | PIM1PIM3PIM2HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL9130628 | 0.82 | HTR3E (0.60) | PIM1PIM3PIM2HTR3EHTR3B | |
| SCHEMBL18794206 | 0.79 | PRKCQ (0.49) | PIM1PIM3PIM2PRKCQPRKCD | |
| SCHEMBL75430 | 0.78 | HTR3E (0.66) | PIM1PIM3PIM2HTR3EHTR3B | |
| SCHEMBL26669816 | 0.77 | PRKCQ (0.48) | PIM1PIM3PIM2PRKCQPRKCD | |
| Hydrochloric Acid SCHEMBL20339484 | 0.77 | HTR3E (0.64) | PIM1PIM3PIM2HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL5364892 | 0.77 | HTR3E (0.64) | PIM1PIM3PIM2HTR3EHTR3B | |
| SCHEMBL234735 | 0.76 | PLD1 (0.60) | PRKCQPRKCDGRIN2BCSNK1EACVR1 | |
| SCHEMBL31745447 | 0.76 | PLD1 (0.60) | PRKCQPRKCDGRIN2BCSNK1EACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538121-B2 | Vanilloid receptor modulators | GLAXO GROUP LIMITED (GB) | 2009-05-26 | — | — | US | disclosed |
| EP-2033953-A1 | Vanilloid receptor modulators | Glaxo Group Limited (GB) | 2009-03-11 | — | — | EP | disclosed |
| US-20060142333-A1 | Vanilloid receptor modulators | MACDONALD GREGOR J | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142333-A1 | Vanilloid receptor modulators | TRPV1, NPSR1, TRPV3 | PIM1 3014/4885PIM3 2582/4885PIM2 2990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.