Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL161203 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL17350110 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL17350107 | 0.95 | TSHR (0.82) | — | |
| Maleic Acid SCHEMBL2046432 | 0.95 | TSHR (1.00) | — | |
| Maleic Acid SCHEMBL613 | 0.95 | — | — | |
| Maleic Acid SCHEMBL2046430 | 0.95 | TSHR (1.00) | — | |
| Fumaric Acid SCHEMBL6875 | 0.95 | TSHR (1.00) | — | |
| Maleic Acid SCHEMBL20487516 | 0.95 | TSHR (1.00) | — | |
| Fumaric Acid SCHEMBL2046433 | 0.95 | TSHR (1.00) | — | |
| Fumaric Acid SCHEMBL623596 | 0.95 | TSHR (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1004 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250367169-A1 | FORMULATIONS FOR PERSONALIZED METHODS OF TREATMENT | FAETH THERAPEUTICS INC (US) | 2025-12-04 | — | — | US | claimed |
| US-12472203-B2 | Composition and method for treating hearing loss | Soundbites Public Benefit Corporation (US) | 2025-11-18 | — | — | US | claimed |
| US-20250268933-A1 | COMPOSITION AND METHOD FOR TREATING HEARING LOSS | Soundbites Public Benefit Corporation | 2025-08-28 | — | — | US | claimed |
| EP-4387615-B1 | LIQUID-LIQUID EXTRACTION OF PURIFIED PSYCHOACTIVE ALKALOID | PSILO SCIENTIFIC LTD (CA) | 2025-07-09 | — | — | EP | claimed |
| EP-4065236-B1 | METHOD FOR THE DECOLORIZATION OF KERATIN MATERIAL THAT HAS BEEN DYED USING A PIGMENT | HENKEL AG & CO KGAA (DE) | 2025-06-11 | — | — | EP | claimed |
| US-12257553-B2 | Separation membrane and methods of preparation thereof | ASPEN PRODUCTS GROUP, INC. (US) | 2025-03-25 | — | — | US | claimed |
| WO-2025059510-A1 | COCA LEAF EXTRACT FOR NEUROPSYCHIATRIC DISORDERS | MAGDALENA BIOSCIENCES, INC. (US) | 2025-03-20 | — | — | WO | claimed |
| WO-2025038498-A2 | COMPOSITION AND METHOD FOR TREATING HEARING LOSS | Soundbites Public Benefit Corporation (US) | 2025-02-20 | — | — | WO | claimed |
| US-20250057875-A1 | COMPOSITION AND METHOD FOR TREATING HEARING LOSS | Soundbites Public Benefit Corporation | 2025-02-20 | — | — | US | claimed |
| US-12220402-B2 | Formulations for personalized methods of treatment | FAETH THERAPEUTICS, INC. (US) | 2025-02-11 | — | — | US | claimed |
| CN-1253544-A | Solid composition suitable for oral administration comprising L-carnitine or alkanoyl-L-carnitine magnesium fumarate | SIGMA TAU IND FARMACEUTI (IT) | 2000-05-17 | — | — | CN | claimed |
| US-6051608-A | SUITABLE FOR PREPARING SOLID COMPOSITIONS USEFUL AS DIETARY/NUTRITIONAL SUPPLEMENTS FOR HUMAN USE AND AS FODDER SUPPLEMENT FOR VETERINARY PURPOSES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2000-04-18 | — | — | US | claimed |
| EP-0979224-A1 | SOLID COMPOSITIONS SUITABLE FOR ORAL ADMINISTRATION COMPRISING L-CARNITINE OR ALKANOYL-L-CARNITINE MAGNESIUM FUMARATE | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2000-02-16 | — | — | EP | claimed |
| JP-2000501622-A | — | — | 2000-02-15 | — | — | JP | claimed |
| EP-0691317-B1 | Non-azide gas generant formulations | TRW AIRBAG SYS GMBH & CO KG (DE) | 2000-01-12 | — | — | EP | claimed |
| CN-1231582-A | Use of bilayer forming emulsifiers in nutritional compositions comprising divalent metal salts | PROCTER & GAMBLE (US) | 1999-10-13 | — | — | CN | claimed |
| EP-0924996-A1 | USE OF BILAYER FORMING EMULSIFIERS IN NUTRITIONAL COMPOSITIONS COMPRISING DIVALENT METAL SALTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-30 | — | — | EP | claimed |
| US-5888563-A | Use of bilayer forming emulsifiers in nutritional compositions comprising divalent mineral salts to minimize off-tastes and interactions with other dietary components | THE PROCTER & GAMBLE COMPANY (US) | 1999-03-30 | — | — | US | claimed |
| WO-1998049134-A1 | SOLID COMPOSITIONS SUITABLE FOR ORAL ADMINISTRATION COMPRISING L-CARNITINE OR ALKANOYL-L-CARNITINE MAGNESIUM FUMARATE | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1998-11-05 | — | — | WO | claimed |
| WO-1998008401-A1 | USE OF BILAYER FORMING EMULSIFIERS IN NUTRITIONAL COMPOSITIONS COMPRISING DIVALENT METAL SALTS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-05 | — | — | WO | claimed |