Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | C1R | P00736 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18795879 | 0.82 | LCK (0.57) | PDE5ALCKNPC1RAB9ATSHR | |
| SCHEMBL14301179 | 0.82 | PDE5A (0.51) | PDE5ALCKNPC1RAB9ATSHR | |
| SCHEMBL2243695 | 0.81 | KDM4E (0.50) | PDE5ANPC1RAB9ATSHRTDP1 | |
| SCHEMBL18323559 | 0.77 | TDP1 (0.54) | PDE5ATDP1KDM4ENPSR1RXFP1 | |
| SCHEMBL28705750 | 0.75 | KDM4E (0.41) | PDE5ANPC1RAB9ATDP1KDM4E | |
| SCHEMBL1788978 | 0.74 | KDM4E (0.65) | KDM4ENPSR1RXFP1L3MBTL1ALDH1A1 | |
| SCHEMBL17007682 | 0.73 | ALDH1A1 (0.51) | PDE5ATSHRTDP1KDM4ENPSR1 | |
| SCHEMBL17432139 | 0.73 | MEN1 (0.54) | PDE5ALCKTDP1KDM4ENPSR1 | |
| SCHEMBL462643 | 0.72 | TDP1 (0.58) | RAB9ATDP1KDM4ENPSR1RXFP1 | |
| SCHEMBL14067142 | 0.72 | TDP1 (0.58) | TDP1KDM4ENPSR1RXFP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3368514-A1 | TRISUBSTITUTEDSILYLPHENOXYHETEROCYCLES AND ANALOGUES | Bayer CropScience Aktiengesellschaft (DE) | 2018-09-05 | — | — | EP | disclosed |
| WO-2017072283-A1 | TRISUBSTITUTEDSILYLPHENOXYHETEROCYCLES AND ANALOGUES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-05-04 | — | — | WO | disclosed |