Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5020719 | 0.98 | MAOB (0.55) | MAPTRXFP1TRPV1HDAC1MAOB | |
| SCHEMBL5020711 | 0.94 | CA2 (0.55) | MAPTRXFP1TRPV1HDAC1MAOB | |
| SCHEMBL25676 | 0.85 | CES1 (0.64) | CA2MAPK1HDAC8HDAC6 | |
| SCHEMBL2846476 | 0.85 | FFAR1 (0.68) | — | |
| SCHEMBL18798802 | 0.85 | LMNA (0.50) | MAPTRXFP1TRPV1HDAC1MAOB | |
| SCHEMBL11139367 | 0.85 | CA2 (0.53) | CA2HPGD | |
| SCHEMBL7642791 | 0.84 | MAPT (0.74) | MAPTRXFP1HDAC1LMNAHDAC2 | |
| SCHEMBL1326081 | 0.84 | MAPT (0.74) | MAPTRXFP1HDAC1LMNAHDAC2 | |
| SCHEMBL21359026 | 0.84 | MAPT (0.74) | MAPTRXFP1HDAC1LMNAHDAC2 | |
| SCHEMBL1404165 | 0.84 | MAPT (0.74) | MAPTRXFP1HDAC1LMNAHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9636298-B2 | Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs | METHYLGENE INC (CA) | 2017-05-02 | — | — | US | disclosed |