Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | FURIN | P09958 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | ACACA | Q13085 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800626 | 0.88 | SMN1; SMN2 (0.48) | BTKF2F10FURINACACB | |
| SCHEMBL18800606 | 0.80 | NQO2 (0.43) | BTKF2MAPTKMT2AHTT | |
| SCHEMBL18800739 | 0.79 | MEN1 (0.39) | BTKF2F10MEN1KMT2A | |
| SCHEMBL18800557 | 0.76 | PRSS1 (0.45) | MAPTKMT2AHTTMAPK10TP53 | |
| SCHEMBL18800738 | 0.74 | TDO2 (0.49) | MAPTKMT2ALMNACYP3A4MAPK1 | |
| SCHEMBL18800716 | 0.73 | PRKCQ (0.37) | BTKF2MAPTGAACYP3A4 | |
| SCHEMBL6115914 | 0.73 | BTK (0.57) | BTKMAPTTDP1 | |
| SCHEMBL18800867 | 0.73 | BTK (0.50) | BTKF10MAPTKMT2AGAA | |
| SCHEMBL18800614 | 0.71 | ERBB2 (0.42) | CYP3A4 | |
| SCHEMBL18800873 | 0.70 | SCN5A (0.37) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |