Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.42 |
| ▸ | FDPS | P14324 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800557 | 0.85 | PRSS1 (0.45) | MAP4K4CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL18800606 | 0.81 | NQO2 (0.43) | BTKMAP4K4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL18800739 | 0.80 | MEN1 (0.39) | BTKPARP10KMT2AF10PRSS1 | |
| SCHEMBL18800873 | 0.78 | SCN5A (0.37) | PRMT6 | |
| SCHEMBL18800479 | 0.75 | BTK (0.54) | BTKMAP4K4FDPSPARP10 | |
| SCHEMBL18800626 | 0.75 | SMN1; SMN2 (0.48) | BTKCYP1A2GAACYP2D6CYP2C19 | |
| SCHEMBL18800610 | 0.73 | BTK (0.43) | BTKMAP4K4GAAMAPTKMT2A | |
| SCHEMBL18800598 | 0.72 | KDM4E (0.51) | CYP1A2CYP2D6CYP2C19MAPTPRSS1 | |
| SCHEMBL18800738 | 0.72 | TDO2 (0.49) | CYP1A2CYP2D6CYP2C19GLAMAPT | |
| SCHEMBL30047284 | 0.70 | MAP4K4 (0.57) | BTKMAP4K4CYP1A2GAACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |