Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 5/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800751 | 0.91 | BTK (0.46) | BTKTNK2 | |
| SCHEMBL18800492 | 0.85 | BTK (0.48) | BTKTNK2 | |
| SCHEMBL18800775 | 0.85 | TNK2 (0.48) | BTKKMT2ATNK2 | |
| SCHEMBL18800616 | 0.84 | BTK (0.47) | BTKTNK2 | |
| SCHEMBL18800753 | 0.84 | BTK (0.49) | BTKTNK2 | |
| SCHEMBL18800755 | 0.84 | TNK2 (0.50) | BTKCHEK2TNK2 | |
| SCHEMBL18800769 | 0.84 | ADORA2A (0.48) | BTKCHEK2TNK2 | |
| SCHEMBL18800482 | 0.83 | BTK (0.40) | BTKTNK2 | |
| SCHEMBL18800882 | 0.83 | BTK (0.42) | BTKTNK2 | |
| SCHEMBL18800641 | 0.82 | BTK (0.42) | BTKTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |