Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 2/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800586 | 0.91 | BTK (0.43) | BTKTNK2 | |
| SCHEMBL18800769 | 0.85 | ADORA2A (0.48) | BTKTNK2 | |
| SCHEMBL18800492 | 0.84 | BTK (0.48) | BTKTNK2 | |
| SCHEMBL18800775 | 0.84 | TNK2 (0.48) | BTKTNK2 | |
| SCHEMBL16168176 | 0.84 | BTK (0.46) | BTKTNK2 | |
| SCHEMBL18800616 | 0.83 | BTK (0.47) | BTKTNK2 | |
| SCHEMBL18800753 | 0.83 | BTK (0.49) | BTKTNK2 | |
| SCHEMBL18800755 | 0.83 | TNK2 (0.50) | BTKTNK2 | |
| SCHEMBL18800482 | 0.82 | BTK (0.40) | BTKTNK2 | |
| SCHEMBL18800749 | 0.82 | TNK2 (0.49) | BTKTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |