Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800677 | 0.89 | MCL1 (0.46) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL18800415 | 0.89 | BTK (0.46) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL18800779 | 0.87 | XDH (0.47) | RAB9AXDH | |
| SCHEMBL18800649 | 0.84 | MEN1 (0.46) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL18800407 | 0.83 | F2 (0.49) | RAB9APLAUPRSS1PRSS2PRSS3 | |
| SCHEMBL18800472 | 0.83 | XDH (0.46) | MEN1KMT2ARAB9AXDHNTSR1 | |
| SCHEMBL18800717 | 0.82 | BTK (0.45) | MEN1KMT2ARAB9AAGTR1PRSS1 | |
| SCHEMBL18800645 | 0.82 | NPC1 (0.45) | RAB9AXDH | |
| SCHEMBL18800785 | 0.82 | MCL1 (0.50) | ACHEADORA2AMAPTALDH1A1KDM4E | |
| SCHEMBL18800806 | 0.81 | BTK (0.49) | MEN1KMT2AMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |