Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | CTRC | Q99895 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800828 | 0.91 | KDM4E (0.42) | BTKKDM4EALDH1A1PDE4APDE4C | |
| SCHEMBL18800670 | 0.89 | ACHE (0.47) | KDM4ERAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL18800839 | 0.87 | ADORA3 (0.41) | BTKCTRCKDM4ENPC1RAB9A | |
| SCHEMBL18800832 | 0.84 | KDM4E (0.39) | BTKKDM4EALDH1A1 | |
| SCHEMBL18800676 | 0.84 | BTK (0.60) | BTKCHEK1KMT2AMAPTNEK2 | |
| SCHEMBL18800817 | 0.84 | TNK2 (0.52) | BTK | |
| SCHEMBL18800710 | 0.84 | ALDH1A1 (0.46) | BTKKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18800917 | 0.84 | CYP1A2 (0.38) | BTKCTRCKDM4ENPC1RAB9A | |
| SCHEMBL16168193 | 0.83 | PARP10 (0.51) | BTK | |
| SCHEMBL18800736 | 0.82 | BTK (0.63) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |