Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PLG | P00747 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800710 | 0.85 | ALDH1A1 (0.46) | BTKRXRARXRBPARP10PRSS1 | |
| SCHEMBL18800415 | 0.84 | BTK (0.46) | BTKKMT2ANEK2MAPTCHEK1 | |
| SCHEMBL18800828 | 0.83 | KDM4E (0.42) | BTKKMT2ANEK2CHEK1 | |
| SCHEMBL18800707 | 0.83 | BTK (0.60) | BTKRXRAPIM3NEK2MAPT | |
| SCHEMBL18800839 | 0.81 | ADORA3 (0.41) | BTKKMT2APLAUNEK2MAPT | |
| SCHEMBL18800736 | 0.79 | BTK (0.63) | BTKMCL1F2 | |
| SCHEMBL16168193 | 0.78 | PARP10 (0.51) | BTKMCL1PARP10F2PRSS1 | |
| SCHEMBL18800799 | 0.78 | DYRK1A (0.49) | KMT2APRSS1MAPT | |
| SCHEMBL16168188 | 0.77 | ALDH1A1 (0.53) | BTKMCL1MAPT | |
| SCHEMBL18800832 | 0.77 | KDM4E (0.39) | BTKF2PLGPLAUPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |