Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800640 | 0.89 | BTK (0.43) | BTKNPC1RAB9A | |
| SCHEMBL18800753 | 0.88 | BTK (0.49) | BTK | |
| SCHEMBL18800492 | 0.87 | BTK (0.48) | BTK | |
| SCHEMBL18800411 | 0.86 | BTK (0.56) | BTKNPC1RAB9A | |
| SCHEMBL18800616 | 0.86 | BTK (0.47) | BTK | |
| SCHEMBL18800564 | 0.85 | BTK (0.47) | BTKNPC1RAB9A | |
| SCHEMBL18800747 | 0.83 | KMT2A (0.46) | BTKNPC1RAB9A | |
| SCHEMBL18800770 | 0.82 | BTK (0.57) | BTK | |
| SCHEMBL18800597 | 0.81 | BTK (0.40) | BTKNPC1RAB9A | |
| SCHEMBL18800651 | 0.81 | BTK (0.43) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |