Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 9/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800753 | 0.96 | BTK (0.49) | BTKTNK2SCN9A | |
| SCHEMBL18800492 | 0.95 | BTK (0.48) | BTKTNK2SCN9A | |
| SCHEMBL18800616 | 0.94 | BTK (0.47) | BTKTNK2SCN9A | |
| SCHEMBL18800747 | 0.91 | KMT2A (0.46) | BTKTNK2MEN1KMT2AALDH1A1 | |
| SCHEMBL18800651 | 0.89 | BTK (0.43) | BTKTNK2 | |
| SCHEMBL18800757 | 0.89 | TNK2 (0.49) | BTKTNK2SCN9A | |
| SCHEMBL16168177 | 0.89 | PARP10 (0.51) | BTKTNK2KMT2AALDH1A1SCN9A | |
| SCHEMBL18800583 | 0.88 | BTK (0.43) | BTKTNK2ALDH1A1LMNAMAPT | |
| SCHEMBL18800776 | 0.88 | BTK (0.49) | BTKTNK2SCN9A | |
| SCHEMBL18800775 | 0.85 | TNK2 (0.48) | BTKTNK2KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |