Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 10/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800492 | 0.85 | BTK (0.48) | ADORA2AADORA1BTKTNK2 | |
| SCHEMBL18800616 | 0.84 | BTK (0.47) | ADORA2AADORA1BTKTNK2 | |
| SCHEMBL18800753 | 0.84 | BTK (0.49) | ADORA2AADORA1BTKTNK2 | |
| SCHEMBL18800775 | 0.83 | TNK2 (0.48) | ADORA2AADORA1BTKTNK2 | |
| SCHEMBL18800769 | 0.82 | ADORA2A (0.48) | ADORA2AADORA1BTKTNK2 | |
| SCHEMBL18800597 | 0.81 | BTK (0.40) | ADORA2ABTKDYRK1A | |
| SCHEMBL18800564 | 0.81 | BTK (0.47) | BTKTNK2 | |
| SCHEMBL18800882 | 0.81 | BTK (0.42) | BTKTNK2 | |
| SCHEMBL18800568 | 0.80 | BTK (0.62) | BTKDYRK1ATNK2 | |
| SCHEMBL18800755 | 0.80 | TNK2 (0.50) | BTKTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |