Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.37 |
| ▸ | METAP2 | P50579 | 4/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | BID | P55957 | 2/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647720 | 0.91 | METAP2 (0.44) | PPARAMETAP2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL18801307 | 0.88 | TDP1 (0.40) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL18801289 | 0.80 | METAP2 (0.41) | METAP2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL1647770 | 0.79 | TSHR (0.41) | KDM4EALDH1A1HSD17B10CA12CA1 | |
| SCHEMBL18801161 | 0.78 | MAPT (0.37) | PTPN1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL18801252 | 0.76 | MEN1 (0.30) | — | |
| SCHEMBL18801131 | 0.76 | HTT (0.31) | METAP2HTT | |
| SCHEMBL18801147 | 0.76 | METAP2 (0.48) | METAP2PPARGKDM4EALDH1A1HSD17B10 | |
| SCHEMBL18801070 | 0.76 | TUBB4A (0.39) | ALDH1A1HSD17B10 | |
| SCHEMBL18801063 | 0.76 | METAP2 (0.48) | METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |