Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801103 | 0.85 | DRD2 (0.40) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL18801106 | 0.84 | DRD2 (0.39) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL18801159 | 0.80 | MEN1 (0.34) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL1648567 | 0.78 | MAPK1 (0.39) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL18801153 | 0.76 | DRD2 (0.46) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL1645658 | 0.75 | DRD2 (0.37) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL1648499 | 0.74 | ALDH1A1 (0.44) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL18801080 | 0.71 | METAP2 (0.41) | — | |
| SCHEMBL1648182 | 0.71 | MEN1 (0.35) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL18801112 | 0.71 | MEN1 (0.35) | DRD2DRD4DRD3MEN1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |