Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | HPGD | P15428 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | GRM6 | O15303 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801172 | 0.91 | RAB9A (0.43) | ALDH1A1HPGDKDM4EGAAMEN1 | |
| SCHEMBL18801327 | 0.89 | PPARG (0.41) | ALDH1A1HPGDKDM4EGAAMEN1 | |
| SCHEMBL1647770 | 0.89 | TSHR (0.41) | ALDH1A1HPGDKDM4EGAAKMT2A | |
| SCHEMBL18801307 | 0.85 | TDP1 (0.40) | ALDH1A1HPGDKDM4EGAAKMT2A | |
| SCHEMBL18801093 | 0.85 | MAPT (0.39) | ALDH1A1HPGDKDM4EGAAKMT2A | |
| SCHEMBL18801310 | 0.85 | ALDH1A1 (0.35) | ALDH1A1HPGDKDM4EGAAMAPT | |
| SCHEMBL18801321 | 0.84 | TSHR (0.35) | ALDH1A1HPGDKDM4EGAAMEN1 | |
| SCHEMBL18801105 | 0.83 | IMPDH2 (0.43) | — | |
| SCHEMBL18801443 | 0.82 | MAPK8 (0.37) | ALDH1A1HPGDKDM4EGAAMAPT | |
| SCHEMBL18801180 | 0.81 | ALDH1A1 (0.37) | ALDH1A1HPGDKDM4EGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |