Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801358 | 0.93 | METAP2 (0.38) | METAP2ALDH1A1KDM4ELMNADRD2 | |
| SCHEMBL18801276 | 0.86 | METAP2 (0.42) | METAP2LMNABCHESCN1ASCN2A | |
| SCHEMBL18801044 | 0.85 | METAP2 (0.44) | METAP2ALDH1A1KDM4ELMNADRD3 | |
| SCHEMBL1648737 | 0.83 | METAP2 (0.46) | METAP2ALDH1A1KDM4ELMNADRD2 | |
| SCHEMBL18801295 | 0.81 | METAP2 (0.38) | METAP2ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL18801061 | 0.80 | METAP2 (0.43) | METAP2ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL18801150 | 0.80 | METAP2 (0.48) | METAP2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18801101 | 0.79 | METAP2 (0.39) | METAP2ACHESCN1ASCN2ASCN3A | |
| SCHEMBL1649341 | 0.79 | METAP2 (0.47) | METAP2ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL18801365 | 0.78 | METAP2 (0.39) | METAP2ALDH1A1KDM4ELMNADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |