Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 10/20 | 0.42 |
| ▸ | SCN1A | P35498 | 3/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801101 | 0.92 | METAP2 (0.39) | METAP2SCN1ASCN2ASCN3AFABP4 | |
| SCHEMBL18801427 | 0.86 | METAP2 (0.42) | METAP2SCN1ASCN2ASCN3ABCHE | |
| SCHEMBL18801044 | 0.86 | METAP2 (0.44) | METAP2FABP4FABP5LMNAHTT | |
| SCHEMBL1648930 | 0.83 | METAP2 (0.47) | METAP2FABP4FABP5 | |
| SCHEMBL18801150 | 0.82 | METAP2 (0.48) | METAP2FABP4FABP5L3MBTL1 | |
| SCHEMBL18801061 | 0.82 | METAP2 (0.43) | METAP2FABP4FABP5LMNA | |
| SCHEMBL1649341 | 0.80 | METAP2 (0.47) | METAP2FABP4FABP5PPARAL3MBTL1 | |
| SCHEMBL18801365 | 0.80 | METAP2 (0.39) | METAP2LMNAHTT | |
| SCHEMBL18801358 | 0.79 | METAP2 (0.38) | METAP2SCN1ASCN2ASCN3ABCHE | |
| SCHEMBL18801045 | 0.77 | ALDH1A1 (0.44) | METAP2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |